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CalcuSyn 劑量效應分析軟體​


CalcuSyn Version 2.0 is the definitive analyzer of combined drug effects, able automatically to quantify phenomena such as synergism and inhibition. Mixed drug treatment is becoming common in the treatment of cancer, AIDS etc, and CalcuSyn is the most widely used software for establishing efficacy in this field. It performs multiple drug dose-effect calculations using the Median Effect methods described by T-C Chou and P. Talalay (Trends Pharmacol. Sci. 4, 450-454).

CalcuSyn can easily be integrated with other software. Data can be entered via the keyboard or file import either into the grid or directly into the analysis engine. When the grid is used, data can be processed through wizards which make the software easily accessible to new users.

Data can be processed both for individual drugs and for constant-ratio or non-constant-ratio combinations of drugs. CalcuSyn automatically graphs the data and produces reports giving summary statistics on all drugs plus detailed analysis of drug interactions including the Combination Index and EDx (for any value of x). Estimates of accuracy of EDx and CI can be calculated with Monte Carlo simulations or by a highly accurate algebraic estimation algorithm. The plots drawn by CalcuSyn include dose-effect, median-effect, isobolograms and CI-effect. All data and results are easily accessible by mouse-click on the contents tree.

CalcuSyn Version 2.0 has Undo and Redo tools. There are flexible arrangements for printing of results and graphs and their export to spreadsheets, wordprocessors, graphics packages etc. A comprehensive manual is supplied as .pdf with the software and there is a detailed Help file. These give a thorough account of the theoretical basis of the analysis methods including the statistical treatment of results. Already used in hundreds of academic labs and pharmaceutical companies, CalcuSyn is indispensable for the study of drug mixtures.​

CalcuSyn 2.0 版是聯合用藥效果的權威分析軟體,能自動量化現象如協同作用和抑製作用。混合藥物治療癌症、艾滋病等的疾病越來越普遍,且 CalcuSyn 是本領域最廣泛使用的軟件。

CalcuSyn 可以很容易地與其他軟件集成在一起。數據可以通過鍵盤或文件導入或直接進入分析引擎。可以通過嚮導使用網格、數據,使得該軟體很容易讓沒有相關背景的新用戶使用。

數據既可以處理個別藥物也可以處理恆定比或非恆比組合藥物。輸入完資料後,CalcuSyn 能自動將數據製成圖表,並生成報告,對所有藥物相互作用的做詳細分析,包括組合指數和 EDX 提供匯總統計。EDX 和 CI 的準確性估計可以用蒙特卡羅模擬或由高度準確的代數估計算法進行計算。能透過 CalcuSyn 設置劑量效應、中值效果、等效線圖和 CI 效果。所有的數據和結果透過滑鼠就能輕易地小事出來。